CV

(updated June 2019)
 

Address

Office: Department of Applied Physiology & Wellness
Southern Methodist University
Annette Simmons Hall Rm # 118 A
Dallas, TX 75205
 
Phone: (214) 768-2193
Fax : (214) 768-4990
 
Email:
Office: spurkayastha@smu.edu
Personal: sushmitap@gmail.com
 

EDUCATION & TRAINING

 

Undergraduate

1992-1995
Bachelor of Science (B.Sc)- Physiology Honors
Department of Physiology
RNLK Women’s College, Vidyasagar University, India 721102
 

Graduate

1995-1997
Master of Science (M.Sc.) –Physiology
Department of Physiology,
University of Calcutta, India 700009
Emphasis: Ergonomics & Work Physiology
Mentor: A.M. Chanda, Ph.D.
 
2003-2005
Master of Science (M.S.)- Exercise Physiology
Department of Kinesiology,
University of Texas at Arlington, TX 76019
Emphasis: Neuromuscular Physiology
Mentor: Joel T. Cramer, Ph.D.
 
2006-2010
Doctor of Philosophy (Ph.D.)- Biomedical Sciences
Department of Integrative Physiology,
University of North Texas Health Science Center at Fort Worth, TX 76107
Emphasis: Cardiovascular & Exercise Physiology
Mentor: Peter B. Raven, Ph.D.
 

Post-doctoral

2011-2014
NIH-T32 Post-doctoral Research Fellow
Institute For Aging Research, Hebrew Senior Life
Harvard Medical School
Boston, MA 02131
 
Post-doctoral Research Fellow in Medicine
Beth Israel Deaconess Medical Center
Harvard Medical School
Boston, MA 02215
Emphasis: Cerebrovascular Physiology in Aging
Mentors: Lewis A. Lipsitz, M.D. & Farzaneh Sorond, M.D., Ph.D.
 

HONORS

1995
Silver Medalist for ranking second in B.Sc., Physiology Honors, Vidyasagar University, India
1997
National Merit Scholarship, Ministry of Human Resource Development, Government of India
2006
Second position in the Masters category, Texas Chapter of the American College of Sports Medicine
2011
President’s Award for Scholarly Excellence, University of North Texas Health Science Center at Fort Worth, TX
2011
Dean’s Award for Scholarly Excellence, University of North Texas Health Science Center at Fort Worth, TX
2012
American Autonomic Society Travel Fellowship, 23rd International Symposium on the Autonomic Nervous System
2014
Research Article selected for Virtual Issue of ‘Women authors in Experimental Physiology today’ containing highly downloaded or cited articles from women (first authors) in Experimental Physiology 2013-2014
 

ACADEMIC POSITIONS

2017-Present
Adjunct Assistant Professor
Department of Physical Medicine & Rehabilitation
University of Texas Southwestern Medical Center
Dallas TX 75390
 
2014-Present
Assistant Professor
Department of Applied Physiology & Wellness
Annette Caldwell Simmons School of Education & Human Development
Southern Methodist University,
Dallas TX 75205
 
2014-2014
Post-doctoral Research Fellow
Athinoula Martinos Center for Biomedical Imaging
Massachusetts General Hospital
Boston MA 02129
 
2011-2013
Post-doctoral Research Fellow
Institute For Aging Research
Harvard Medical School
Boston MA 02131
 
2011-2013
Post-doctoral Research Fellow in Medicine
Beth Israel Deaconess Medical Center
Harvard Medical School
Boston MA 02215
 
2006-2010
Graduate Research Assistant
Department of Integrative Physiology
UNT Health Science
Fort Worth TX 76107
 
2005-2006
Senior Research Assistant
Department of Integrative Physiology
UNT Health Science Center
Fort Worth TX 76107
 
2004-2005
Research Assistant
Department of Kinesiology
University of Texas at Arlington
Arlington TX 76019
 
2003-2004
Teaching Assistant,
Department of Kinesiology
University of Texas at Arlington
Arlington TX 76019
 

GRANTS

2016-2018
Pilot project grant from the Texas Institute for Brain Injury and Repair at UT Southwestern Medical Center to examine the association between cerebrovascular hemodynamics and clinical symptoms in sports related concussion.
Site PI: Sushmita Purkayastha
Total Budget: $222,801 (SMU subcontract: $186,285)
 
2015-2016
University Research Council Grant at Southern Methodist University to examine cerebral blood flow regulation in sports related traumatic brain injury.
PI: Sushmita Purkayastha
Budget: $ 3,892
 
2011-2013
NIH T32 Grant (5 T32 AG 23480-7) for translational research in aging to examine physical activity and cerebral blood flow regulation in healthy elderly people.
Role: Post-doctoral Research Fellow
Budget: $ 52,428 (annually)
 

PUBLICATIONS

Manuscripts published in Peer-Reviewed Journals
 
Purkayastha S, Stokes M, and Bell KR. Autonomic Nervous System Dysfunction in Mild Traumatic Brain Injury: A Review of Related Pathophysiology and Symptoms. Brain Injury, 2019. Accepted for Publication.
 
Purkayastha S, Williams B, Murphy MN, Lyng S, Sabo T, and Bell KR. Reduced Heart Rate Variability and Lower Cerebral Blood Flow Associated with Poor Cognition during Recovery following Concussion. Autonomic Neuroscience: Basic and Clinical, 2019. Epub ahead of print: https://doi.org/10.1016/j.autneu.2019.04.004
 
Purkayastha S., Adair H, Woodruff A, Ryan LJ, Williams B, James E, and Bell KR. Balance Testing Following Concussion: Postural Sway versus Complexity Index. Physical Medicine & Rehabilitation Journal, 2019. Accepted for Publication. https://doi.org/10.1002/pmrj.12129
 
Purkayastha S, Sorond FA, Lyng S, Frantz J, Murphy MN, Hynan LS, Sabo T, and Bell KR. Impaired Cerebral Vasoreactivity Despite Symptom Resolution in Sports-Related Concussion. Journal of Neurotrauma, 2018. DOI: https://doi.org/10.1089/neu.2018.5861
 
Huang M, Frantz J, Moralez G, Sabo T, Davis, PF, Davis SL, Bell KR, Purkayastha S. Reduced Resting and Increased Elevation of Heart Rate Variability with Cognitive Task Performance in Concussed Athletes. Journal of Head Trauma & Rehabilitation, 2018. 34(1);45-51.
 
Purkayastha S Maffuid K, Xiaojie Z, Zhang R, and Raven PB. The Influence of Carotid Baroreflex on Dynamic Regulation of Cerebral Blood Flow and Cerebral Tissue Oxygenation in Humans at Rest and During Exercise. European Journal of Applied Physiology. 2018; 118(5), 959-969.
 
Sabo T, Supnet C and Purkayastha S*. Secondary intracranial hypertension (pseudotumor cerebri) presenting as post-traumatic headache in mild traumatic brain injury: a case series. Child’s Nervous System. 2018, 34: 681-690.
 
Purkayastha S and Sorond FA. Cerebral Hemodynamics and the Aging Brain. International Journal of Clinical Neurosciences and Mental Health. 2014; (Suppl.1): S07.
 
Fadar O, Mink S, Tan OT, Puri A, Zamani A, Mehregan A, Chou SH, Orzell S, Purkayastha S, Du R, Sorond FA. Impaired Cerebral Autoregulation is Associated with Vasospasm and Delayed Cerebral Ischemia in Subarachnoid Hemorrhage. Stroke, 2014; 45:677-682.
 
Purkayastha S, Fadar O, Mehregan A, Salat DH, Guttmann CRG, Fisher NDL, Lipsitz LA, Sorond FA. Impaired cerebrovascular hemodynamics are associated with cerebral white matter damage. Journal of Cerebral Blood Flow and Metabolism. 2014; 34, 228-234.
 
Purkayastha S and Sorond FA. Transcranial Doppler Ultrasound: Technique and Application. Seminars in Neurology, 2012; 32(04): 411-420.
 
Purkayastha S, Saxena A, Eubank WL, Hoxha B, and Raven PB. Alpha Adrenergic receptor control of the cerebral vasculature in humans at rest and during exercise. Experimental Physiology, 2013; 98(2), 451-61.
 
Purkayastha S and Raven, PB. The functional role of the alpha-1 adrenergic receptors in cerebral blood flow regulation. Indian Journal of Pharmacology. 2011 Sep-Oct; 43(5): 502–506.
 
Hawkins MN, Barnes Q, Purkayastha S, Eubank W, Ogoh S, Raven PB. The effects of aerobic fitness and beta1-adrenergic receptor blockade on cardiac work during dynamic exercise. Journal of Applied Physiology. 2009 Feb; 106 (2): 486-93.
 
Ogoh S, Fisher JP, Purkayastha S, Dawson EA, Fadel PJ, White MJ, Zhang R, Secher NH, Raven PB. Regulation of middle cerebral artery blood velocity during recovery from dynamic exercise in humans. Journal of Applied Physiology. 2007 Feb; 102(2): 713-21.
 
Cramer JT, Beck TW, Housh TJ, Massey LL, Marek SM, Danglemeier S, Purkayastha S, Culbertson JY, Fitz KA, Egan AD. Acute effects of static stretching on characteristics of the isokinetic angle - torque relationship, surface electromyography, and mechanomyography. Journal of Sports Science. 2007 Apr 25(6): 687-98.
 
Ogoh, S, Brothers RM, Barnes Q, Eubank WL, Hawkins MN, Purkayastha S, O-Yurvati A, Raven PB. Cardiopulmonary baroreflex is reset during dynamic exercise. Journal of Applied Physiology. 2006 Jan; 100(1): 51-9.
 
Ogoh S, Brothers RM, Barnes Q, Eubank WL, Hawkins MN, Purkayastha S, O-Yurvati A, Raven PB. Effects of changes in central blood volume on carotid-vasomotor baroreflex sensitivity at rest and during exercise. Journal of Applied Physiology. 2006 Jul; 101(1): 68-75.
 
Purkayastha S, Cramer JT, Trowbridge CA, Fincher AL, Marek SM. Surface electromyographic amplitude-to-work ratios during isokinetic and isotonic muscle actions. Journal of Athletic Training. 2006 Jul-Sep; 41(3): 314-20.
 
Ogoh S, Brothers RM, Barnes Q, Eubank WL, Hawkins MN, Purkayastha S, O-Yurvati A, Raven PB. The effect of changes in cardiac output on middle cerebral artery mean blood velocity at rest and during exercise. Journal of Physiology. 2005 Dec 1; 569(Pt 2):697-704.
 
Marek SM, Cramer JT, Fincher AL, Massey LL, Dangelmaier SM, Purkayastha S, Fitz KA, Culbertson JY. Acute Effects of Static and Proprioceptive Neuromuscular Facilitation Stretching on Muscle Strength and Power Output. Journal of Athletic Training. 2005 Jun; 40(2): 94-103. *Authors contributed equally
 
 

Manuscripts in Preparation

 
Purkayastha S, Ryan L, Lyng S, Wainman M, Sabo T, and Bell K. Dynamic Cerebral Autoregulation Impairment at Rest and During Physical Stress Persists Despite Symptom Resolution in Collegiate Athletes Following Concussion. To be submitted to Journal of Cerebral Blood Flow & Metabolism.
 
Purkayastha S, Lyng S, Brown E, Sabo T, Bell KR. Dysregulation in Neurovascular Coupling Persists During Sub-Acute Phase Following a Sports-Related Concussion. To be submitted to Journal of Cerebral Blood Flow & Metabolism.
 
Purkayastha S, Stokes M, Sabo T. Pathophysiology of cerebral edema in mild traumatic brain injury- A Review of Literature. To be submitted to Journal of Neuroinflamation.
 
 

Published Abstracts (Oral & Poster Presentation)

Purkayastha S, Lyng S, Brown EK, Sabo T, and Bell KR. Dysregulation in Neurovascular Coupling Persists During Sub-Acute Phase Following a Sports-Related Concussion. 13th World Congress on Brain Injury 2019, Toronto, Canada, March 15th (Poster Presentation).
 
Brown EK, Lyng S, Ryan L, Bell K and Purkayastha S. Despite Symptom Resolution Dynamic Cerebral Autoregulation is Impaired in Collegiate Athletes Following Concussion. Texas chapter of American College of Sports Medicine Annual Conference, 2019, February 28th (Student Poster Presentation).
 
Lyng S, Brown EK, Sabo T, Bell KR and Purkayastha S. Persistent Neurovascular Coupling Dysregulation During Subacute Recovery Phase Following Concussion. Texas chapter of American College of Sports Medicine Annual Conference, 2019, February 28th (Student Poster Presentation).
 
Purkayastha S, Frantz J, Hynan H, Sabo T, Sorond FA, Bell KR. Cerebral Vasoreactivity is Impaired Three Month Following Sports Related Concussion in Collegiate Athletes. 4th Federal Interagency Conference on Traumatic Brain Injury, Washington DC, June 12th 2018 (Oral presentation).
 
Purkayastha S, Frantz J, Sedaghat S, Ryan L, Lyng S, Wainman M, Sabo T, and Bell K. Dynamic Cerebral Autoregulation Impairment at rest and During Physical Stress Persists Despite Symptom Resolution in Collegiate Athletes Following Concussion. North America Brain Injury Society Annual Meeting, Houston, TX, March 17th 2018 (Oral Presentation).
 
Frantz J, Sedaghat S, Ryan L, Wainman M, Lyng S, Sabo T, Bell KR, Purkayastha S. Dynamic Cerebral Autoregulation Impairment Persists Past Resolution of Symptoms in Collegiate Athletes Following Concussion. Experimental Biology, April 21st, 2018, San Diego, CA (Student Oral presentation).
 
Woodruff A, Frantz J, Ryan Laurence, Davis PF, Purkayastha S. Physiological Complexity of Postural Control is Impaired Despite Resolution of Postural Sway Following Sport-Related Concussion. Texas chapter of American College of Sports Medicine Annual Conference, March 1st, 2018 (Student Poster Presentation).
 
Wainman M, Frantz J, Williams B, Lyng S, Sabo T, Bell KR, Purkayastha S. Cardiac Vagal Tone Impairment is Associated with Reduced Cerebral Blood Flow in Collegiate Athletes Following Concussion. Texas chapter of American College of Sports Medicine Annual Conference, March 1st 2018, Austin, TX (Student Poster Presentation).
 
Lyng S, Frantz J, Wainman M, Sabo T, Bell KR, Purkayastha S. Persistent Impairment in Cerebral Vasoreactivity in Subacute Phase Following Concussion. Texas chapter of American College of Sports Medicine, March 1st 2018, Austin, Texas (Student Poster Presentation).
 
Frantz J, Ryan LJ, Davis PF, Sabo T, Bell KR, Purkayastha S. Physiological Complexity of Postural Control Is Impaired Despite Resolution of Postural Sway Following Sport-Related Concussion. 2017 Sports Concussion Conference. (Student Poster Presentation).
 
Ferraro Madison S, Huang Mu, Frantz J M, Sabo T, Bell KR, and Purkayastha S. Improvement in Heart Rate Variability during Mild Cognitive Task Following Concussion. Texas chapter of American College of Sports Medicine, 2017, Waco, Texas (Student Poster Presentation).
 
Purkayastha S, Frantz J, Sabo T, Bell K. Impaired Cerebral Vasoreactivity Persists Beyond Symptom Resolution Following Concussion in Collegiate Athletes. 12th World Congress on Brain Injury 2017, New Orleans, Louisiana (Oral Presentation).
 
Sabo T.M, Supnet C, Purkayastha S. Post traumatic intracranial hypertension (Pseudotumor cerebri) in mild traumatic brain injury: a specific post-traumatic headache subtype; the importance of recognition, evaluation and management. 12th World Congress on Brain Injury 2017, New Orleans, Louisiana. Brain Injury 2017; 31 (6-7), 736-73 (Poster presentation)
 
Purkayastha S, Maffuid K, Murphy M, Sorond F, Tan CO. Cerebral Autoregulation is Impaired during the Acute and Sub-Acute Phase Following Concussion: A Pilot Study. 16th International Symposium on Intracranial Pressure and Neuromonitoring in conjunction with 6th Annual Meeting of the Cerebral Autoregulation Network, 2016. (Poster Presentation).
 
Maffuid K, Murphy MN, Davis PF, Purkayastha S. Cerebral Vasoreactivity During Acute and Recovery Phase Post-Concussion: A Pilot Study. Texas chapter of American College of Sports Medicine, 2016. (Student Poster Presentation).
 
Maffuid K, Ryan L, Murphy MN, Davis PF, Purkayastha S. Improvement in Cerebral Autoregulation During Recovery Phase Following Concussion is Associated with Reduced Postural Sway: A Pilot Study. Experimental Biology, 2016 (Control # 7015, Student Poster Presentation).
 
Purkayastha S, Sorond FA, Tan CO. Effect of Desferroxamine Infusion on Cerebral Autoregulation in Elderly Individuals: A Randomized Placebo Controlled Trial. Experimental Biology, 2015 (Control # 6770, Poster Presentation).
 
Sorond FA, Purkayastha S, Lipsitz LA, Leveille SG. Impaired Cerebral Autoregulation is associated with a Greater 7-year Decline in Gait Speed in an Elderly Population: The MOBILIZE Boston Study. American Academy of Neurology, 2014 (S58.007, Oral Presentation).
 
Purkayastha S, Fadar O, Mehregan A, Lipsitz LA, Sorond FA. Association between Cerebral tissue Structural Integrity and Dynamic Cerebral Autoregulation in Elderly Individuals. Experimental Biology, 2013. (Oral and Poster presentation).
 
Paccha B, Purkayastha S, Sorond FA, Lipsitz LA. Dynamic Cerebral Autoregulation, cognition and physical function in advanced age. The New England Science Symposium, (Student Poster Presentation).
 
Sushmita Purkayastha, Blanca Paccha, Ikechukwu Iloputaife, Dan K. Kiely, Farzaneh A. Sorond, Lewis A. Lipsitz. Association between Cerebral Autoregulation and White Matter Hyperintensities in Elderly Individuals. 23rd International Symposium on the Autonomic Nervous System, October 2012 (Oral Presentation).
 
Purkayastha S, Saxena, A., Raven, P.B. Functional Role of Alpha-1 Adrenergic Receptors in regulating Cerebral Vascular tone in Healthy Humans during Exercise. Experimental Biology, 2011. Poster # D553, 1054.6. (Poster Presentation).
 
A. Saxena, S. Purkayastha, P.B. Raven, and X.Shi. Effect of cycling exercise on dynamic cerebral autoregulation in humans. Experimental Biology, 2011. Poster # D577, 1056.14. (Poster Presentation).
 
Sushmita Purkayastha, Ashwini Saxena, Peter B. Raven. Carotid baroreflex regulation of the cerebral vasculature in humans during rest and dynamic exercise. American College of Sports Medicine Annual Meeting, 2011. 2656, Board # 264. (Poster Presentation).
 
Purkayastha, S, Zhang, R. Levine, B., Raven, PB. The Influence of Autonomic Neural Control on Human Cerebral Vessels ‘in vivo’. 21st International Symposium on the Autonomic Nervous System, 2010. Board# 16 (Poster presentation).
 
Sushmita Purkayastha, R. Mathew Brothers, Peter B. Raven & Shigehiko Ogoh. Effect of angiotensin (AT1) receptor blockade on cerebral autoregulation in healthy human subjects at rest. Texas chapter of American College of Sports Medicine, 2008. (Poster Presentation).
 
Sushmita Purkayastha, Shigehiko Ogoh, David M. Keller, and Peter B. Raven. Modulation of vascular impedance in the femoral artery of humans with neck pressure and neck suction with KATP channel blockade. Texas chapter of American College of Sports Medicine 2006. (Poster Presentation).
 
Sushmita Purkayastha, Joel T. Cramer, PhD. Department of Kinesiology, University of Texas at Arlington. Electromyographic amplitude-to-work (EMG:WK) ratios during isotonic and isokinetic leg extension exercises. Texas chapter of American College of Sports Medicine 2005. (Poster Presentation).
 
 

PRESENTATIONS

Invited Presentations
 
Cerebral Blood Flow Regulation Following a Sports-Related Concussion. BrainHealth Frontiers scientific lecture series sponsored by Center for BrainHealth, Dallas, Tx. October 12th, 2018.
 
Heads Up: Diagnosing and Treating Concussion. Simmons Research Brown Bag Series. SMU Simmons School of Education & Human Development. September 20th, 2017.
 
Cerebral Blood Flow Regulation and Clinical Symptoms in Sports Related Concussion. Grand Rounds Presentation at the Department of Physical medicine & Rehabilitation at UT Southwestern Medical Center, December 2nd, 2016.
 
Aging and Brain Health: The Link Between Brain Structure and Function. Research on Exercise and Wellness Colloquium Series Department of Applied Physiology & Wellness, October 2014.
 
Aging and Brain Health: Association between Cerebral Tissue Integrity and Vascular Function. Department of Applied Physiology, Southern Methodist University, April 2014.
 
Healthy Aging. Senior Living Facilities, 2013, Boston.
 
Association Between Cerebral Tissue Structural Integrity and Cerebral Hemodynamics in Elderly Individuals. Division of Gerontology Meeting, Harvard Medical School, Boston, May 2013.
 
 

National & International Presentations

Cerebral Vasoreactivity is Impaired Three Month Following Sports Related Concussion in Collegiate Athletes. 4th Federal Interagency Conference on TBI, June 12th, 2018, Washington D.C.
 
Dynamic Cerebral Autoregulation Impairment at Rest and During Physical Stress Persists Despite Symptom Resolution in Collegiate Athletes Following Concussion. North America Brain Injury Society Annual Conference, March 17th, 2018, Houston, Texas.
 
Impaired Cerebral Vasoreactivity Persists Beyond Symptom Resolution Following Concussion in Collegiate Athletes. International Brain Injury Association Conference, March 31st, 2017
 
Association between Cerebral tissue Structural Integrity and Dynamic Cerebral Autoregulation in Elderly Individuals. Experimental Biology, 2013.
 
ssociation between Cerebral Autoregulation and White Matter Hyperintensities in Elderly Individuals. 23rd International Symposium on the Autonomic Nervous System, October 2012.
 
 

TEACHING RESPONSIBILITIES

 

Academic Course Development

 
2014
APSM 5300
Senior Project – A Research Methods course
Southern Methodist University
2015
APSM 4312
Advanced Exercise Physiology
Southern Methodist University
2015
APSM 5361
Research Practicum
Southern Methodist University
2017
EDU 7300
Independent Study
Southern Methodist University
 

Academic Course

 
2014
APSM 5300
Senior Project – A Research Methods course
Southern Methodist University
2015
APSM 4412
Advanced Exercise Physiology
Southern Methodist University
2015
APSM 5361
Research Practicum
Southern Methodist University
2012
Summer internship
Cerebrovascular Physiology
Institute For Aging Research, Harvard Medical School
2003
KINE 3315
Physiology of Exercise Laboratory
University of Texas at Arlington
2004
KINE 3301
Biomechanics of Human Movement Laboratory
University of Texas at Arlington
 

PROFESSIONAL AND PUBLIC SERVICE

 

Department Services

 
Phd Committee Member
Mu Huang in Applied Physiology & Wellness Department
Dustin Allen PhD Applied Physiology & Wellness Department
 
Member
Department Distinctions and Honors Committee
 

Simmons School of Education Services

 
2014-2017
Ph.D. Program Committee
 
2016-2018
Faculty Advisor
Simmons Graduate Council
School of Education & Human Development
 
2018-Present
Simmons Library Committee
 

Public Services

 
Invited Speaker
Participation in Research Development site visit in the Department of Physical Medicine & Rehabilitation UT Southwestern Medical Center, December 2016
 
Journal Referee
The Journal of Physiology
Experimental Physiology
Journal of Applied Physiology
The Indian Journal of Pharmacology
Journal of Neurological Sciences
American Journal of Physiology: Regulatory, Integrative and Comparative Physiology
Journal of Cerebral Blood Flow & Metabolism
Frontiers in Human Neuroscience
 
Grant Referee
Natural Sciences and Engineering Research Council of Canada, Discovery Grant Application
 
Scholarship Oversight Committee Member
Danyal Thaver, Critical Care Medicine Fellow, Department of Pediatrics, UT Southwestern Medical Center.
 
Research Advisor
Mathew Stokes, Headache Medicine Fellow, Department of Pediatrics, UT Southwestern Medical Center
 

Professional Affiliations

 
2004- Present
Member
Texas Chapter of American College of Sports Medicine
2009- Present
Regular Member
American Physiological Society
2012- Present
Member
American Autonomic Society
2012- Present
Early Career Member
American Heart Association
2015- Present
Member
Cerebral Autoregulation Network
2016- Present
Member
International Brain Injury Association
2018- Present
Member
North America Brain Injury Society